Researchers reported an immune‑evasive approach to insert kilobase-scale DNA payloads into mammalian genomes without triggering toxic innate immune responses. Teams developed circular single-stranded DNA donors and 'stealth' DNA circles that remain non-immunogenic while preserving compatibility with recombinases and other genome editors, enabling large non-viral insertions in mouse liver when delivered by LNPs. The studies—published in leading journals and corroborated by independent groups—show that standard double-stranded DNA donors provoke cGAS–STING-mediated toxicity, whereas engineered circular donors avoid cytosolic DNA sensing. Experiments demonstrated successful tissue integration and improved tolerability compared with conventional dsDNA donors. Authors and collaborators framed the technology as a step toward scalable genetic medicines that can address diverse mutation spectra within single genes—moving the field beyond bespoke single-mutation fixes toward more generalizable gene-replacement strategies.