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T‑cell receptor therapy stalls in ovarian cancer — hurdles persist
Investigators surveying the state of T‑cell receptor (TCR) therapy for ovarian cancer report persistent translational challenges despite promising biology. Obstacles include antigen heterogeneity...
Wearables flag preflare physiology in rheumatoid arthritis
A multi‑institutional study finds that wearable sensors can detect physiological changes that precede symptomatic inflammatory and symptomatic flares in rheumatoid arthritis patients. The devices...
Fucosidase is required for rotavirus and norovirus replication
Parsons and co‑authors demonstrate that rotavirus and norovirus replication depends on host fucosidase activity required for processing fucose‑containing glycans used by these viruses during...
FDA plan to speed biosimilars: patent office tightening could stall rollout
The FDA announced a proposal to streamline biosimilar regulation to mirror generic drug pathways, aiming to cut development time and cost for copycat biologics. Industry leaders including Stefan...
ACE2 decoy receptor... neutralizes mutant SARS‑CoV‑2 variants
Researchers led by Lin et al. designed an ACE2 decoy receptor that neutralizes multiple SARS‑CoV‑2 variants, demonstrating activity against mutant spike proteins in preclinical assays. Published...
Single 2‑ml mirikizumab injection matches two 1‑ml doses — administration simplified
A pharmacokinetic study led by Otani, Payne and Loftus demonstrated that a single 2‑ml subcutaneous injection of mirikizumab is bioequivalent to two 1‑ml injections in healthy participants. The...
Sibiriline halts two cell‑death programs — a dual inhibitor emerges
Scientists reported a novel small molecule, Sibiriline, that simultaneously inhibits necroptosis and ferroptosis in preclinical models. The study describes Sibiriline’s biochemical activity...
mTORC1 in ILC2s links nerves to allergic lung inflammation
Wang, Hu, Chen and colleagues published a Nature Communications paper demonstrating that mTORC1 signaling in group 2 innate lymphoid cells (ILC2s) couples neuro‑immune inputs to allergic lung...
Plasma LPS levels forecast mortality in acutely ill children
A multicenter study in low‑ and middle‑income countries found that plasma lipopolysaccharide (LPS) concentrations strongly predict mortality among acutely ill children. Researchers measured...
CRISPR assay flags BK and JC viruses after kidney transplant
Liu, Xu, Cao and team developed a CRISPR‑based diagnostic that detects BK and JC polyomaviruses in post‑kidney transplant patients. The assay combines sequence‑specific CRISPR detection with rapid...
Genetic evidence ties gut microbiota to human bone mass
A 2025 Nature Communications study used human genetic analyses to link gut microbiota composition with bone mass regulation. The authors leveraged population genetics and host‑microbe association...
Ferroptosis implicated in sepsis and gastric cancer — targets multiply
Two independent studies highlighted ferroptosis as a central mechanism in both sepsis pathogenesis and gastric cancer therapy resistance. One paper describes how ferroptotic cell death pathways...
Tumor immunity rewired: complement genes and TBK1/IKKε inhibition
Two mechanistic oncology studies mapped complementary ways to reshape tumor immunity. A Nature Communications paper dissected how germline and somatic variation in complement cascade genes...
FDA’s biosimilar push hits patent office
U.S. regulators announced a plan to streamline approval of biosimilars to make copycat biologics cheaper and faster to market, but industry officials warn the U.S. Patent and Trademark Office is...
ACE2 decoy receptor... Blocks mutant SARS-CoV-2
Researchers led by Lin et al. reported an engineered ACE2 decoy receptor that neutralizes multiple SARS-CoV-2 variants in vitro, including escape mutants. The work, published in the Journal of...
CRISPR assay detects BK and JC viruses in transplant patients
A CRISPR-based diagnostic developed by Liu, Xu, and Cao rapidly detects BK and JC viruses in post-kidney-transplant patients, improving surveillance timelines for polyomavirus reactivation. The...
Ferroptosis drives sepsis — IgG levels predict outcomes
New mechanistic work links ferroptosis, an iron-dependent form of cell death, to sepsis pathogenesis and organ dysfunction. The study maps lipid peroxidation and iron-handling pathways activated...
Sibiriline: first dual inhibitor of necroptosis and ferroptosis
Researchers disclosed Sibiriline, a small molecule that simultaneously inhibits necroptosis and ferroptosis in preclinical models. The compound blocks key effectors in both cell-death pathways and...
Cathepsin L dual hit... Targets tumor growth and muscle wasting
A Nature Communications study identifies Cathepsin L as a shared driver of tumor progression and cancer-associated muscle wasting. Investigators used genetic and pharmacologic inhibition to show...
Mirikizumab: single 2-ml injection bioequivalent to two 1-ml shots
A pharmacokinetic study led by Otani, Payne, and Loftus reported that a single 2‑ml subcutaneous injection of mirikizumab is bioequivalent to two separate 1‑ml injections in healthy volunteers....