Researchers adapted a previously developed gene‑drive strategy and tested it in secure facilities in Tanzania, engineering Anopheles mosquitoes to express antiparasitic effectors (MM‑CP) and demonstrating reduced Plasmodium falciparum oocyst growth and sporozoite output from genetically diverse parasite isolates collected from infected children. The study moved gene‑drive work out of the lab into a local ecological context to validate breadth of transmission‑blocking activity. Investigators housed the modified strains in a secure Tanzanian facility and reported delayed parasite migration to salivary glands and lower sporozoite yields, validating prior lab data and representing a step toward real‑world applicability under contained conditions. The work was published in Nature and highlights biosafety and regulatory pathways needed for field translation.