Get the Daily Brief
Latest Biotech News
Nanoparticle Drug Delivery System Enhances Stability and Loading Capacity
Scientists at Xi’an Jiaotong-Liverpool University and Nanjing University have developed a novel protein-polymer coassembly supraparticle by combining PLGA with human serum albumin, yielding...
Gilead’s Lenacapavir Approved as Twice-Yearly HIV Prevention Shot
The FDA has approved Gilead Sciences' lenacapavir (Yeztugo) for pre-exposure prophylaxis (PrEP) as the first twice-yearly injectable drug for HIV prevention. Clinical trials involving diverse...
Prothena Cuts Workforce After Amyloidosis Drug Failure
Prothena announced a major restructuring involving layoffs of approximately 63% of staff following the unsuccessful phase 3 trial of birtamimab, a monoclonal antibody aimed at treating advanced AL...
Neuroscience Study Identifies Thalamic Neurons Governing Sleep Recovery
Researchers at Johns Hopkins University have identified a subset of excitatory neurons in the thalamic nucleus reuniens (mRE) as key regulators of sleep homeostasis. Activation of these neurons in...
Novel CAR T-Cell Therapy Employed to Treat Severe Autoimmune Neuropathy
A clinical milestone has been achieved at Ruhr-University Bochum with the first successful application of chimeric antigen receptor (CAR) T-cell therapy to treat chronic inflammatory demyelinating...
Advances in Single-Cell Transcriptomics Reveal PTSD-Linked Brain Cell Dysregulation
New insights into post-traumatic stress disorder (PTSD) reveal alterations in cellular communication within the prefrontal cortex involving inhibitory neurons, microglia, and other glial cells....
Discovery of Lanthanide-Carbon Triple Bond Encapsulated in Fullerene Cage
An international collaboration led by Jiang et al. has reported the synthesis and characterization of a cerium-carbide cluster exhibiting a lanthanide–carbon triple bond stabilized inside a C80...
H5N1 Virus Immune Evasion Unveiled by AI
Scientists at the University of North Carolina at Charlotte have used advanced artificial intelligence models, including AlphaFold 3, to analyze over 1,800 viral proteins of the H5N1 avian...
Advanced Polymeric Membranes for Precision Ion Transport
Researchers from the Dalian Institute of Chemical Physics have developed ultrathin polymeric membranes using an interfacial polymer cross-linking method that creates nanoscale separation layers...
Interstitial Fluid’s Role in Tissue Mechanics Explored
An MIT engineering team has unveiled the critical influence of intercellular fluid—the watery medium occupying spaces between cells—on tissue flexibility and mechanical response under deformation....
Advances in Pediatric Pharmacogenetics for Drug Personalization
The emerging domain of pediatric pharmacogenetics seeks to optimize medication regimens based on genetic variation influencing drug metabolism in children. Unlike adult populations, pediatric...
Breakthrough Canine Mesenchymal Stem Cell Generation from iPSCs
Osaka Metropolitan University researchers report a novel method for producing high-quality canine mesenchymal stem cells derived from induced pluripotent stem cells sourced from various somatic...
Novel Fusion Architecture Employs Semi-Supervised Learning for Parkinson’s Detection via Speech
Researchers have pioneered a fusion architecture combining multiple machine learning models employing semi-supervised speech embeddings to detect Parkinson’s disease through subtle vocal...
Innovative Nanoparticle System Enhances Drug Delivery Stability and Loading
Scientists from Xi’an Jiaotong-Liverpool University and Nanjing University have engineered a protein-polymer coassembly supraparticle combining PLGA polymer and albumin protein, achieving...
FDA Initiates Pilot Program for Accelerated Drug Review Supporting National Priorities
FDA Commissioner Marty Makary announced a pilot Commissioner’s National Priority Voucher (CNPV) program aimed at expediting the review of medicines that address U.S. national interests, including...
Prothena Cuts Workforce by 63% After Phase 3 Amyloidosis Drug Failure
Biotech company Prothena announced a substantial workforce reduction, laying off 63% of its employees following the failure of its phase 3 trial for the monoclonal antibody birtamimab targeting...
Lanthanide–Carbon Triple Bond Discovery in Fullerene
Researchers have achieved a landmark breakthrough in organometallic chemistry by isolating a lanthanide–carbon triple bond encapsulated within a fullerene cage. This study reports the synthesis...
Menin Inhibition Emerges for Acute Leukemia Treatment
In a critical advancement against aggressive acute leukemias, menin inhibitors are gaining traction as novel targeted therapies. AML and ALL, characterized by uncontrolled proliferation due to...
In Vivo CAR T Cell Generation via Targeted Lipid Nanoparticles
A transformative innovation in immunotherapy has been unveiled whereby chimeric antigen receptor (CAR) T cells can be generated directly within patients rather than ex vivo. By utilizing lipid...
Gilead’s Lenacapavir FDA Approval for Twice-Yearly HIV Prevention
Gilead Sciences received FDA approval for its long-acting injectable HIV pre-exposure prophylaxis drug, lenacapavir (Yeztugo), marking a major step forward in preventing HIV infection....