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AI and CRISPR Advance Cancer Immunotherapy: Genetic Screens Enhance CAR T Cell Efficacy
Researchers at Mass General Brigham and the Broad Institute leveraged CRISPR screens to identify gene knockouts that improve CAR T cell function and persistence against multiple myeloma. Using...
FDA Clears Subcutaneous Keytruda: First One-Minute Immune Checkpoint Injection
The FDA approved Merck’s Keytruda Qlex, a subcutaneously administered combination of pembrolizumab and berahyaluronidase alfa, becoming the first immune checkpoint inhibitor delivered under a...
Sanofi Boosts Venture Capital with $625M Cash Infusion for Biotech Investments
Sanofi has bolstered its corporate venture capital arm, Sanofi Ventures, with an additional $625 million, bringing total committed capital to approximately $1.4 billion. The financing aims to...
Breakthrough RSV Preventatives Cut Infant Illness and Death, Expanding Protection
2023 saw the approval of the first single-dose RSV vaccine and monoclonal antibody treatments, offering unprecedented protection against severe respiratory syncytial virus infection in infants and...
Triclabendazole Blocks PKM2 Enzyme, Disrupting Lung Cancer Metabolism
A novel application of triclabendazole, traditionally an antiparasitic drug, has demonstrated promising activity against lung cancer by targeting the enzyme Pyruvate Kinase M2 (PKM2). This...
New ‘Live-seq’ Workflow Enables Non-Damaging Live-Cell RNA Sequencing for Dynamic Studies
Cytosurge and Lexogen have launched the first commercial integrated Live-seq workflow, enabling repeated RNA sequencing of the same living cells with minimal invasiveness. This breakthrough...
AI-Driven Virtual Specialty Care Platform AmplifyMD Raises $20M Series B
AmplifyMD secured $20 million in Series B funding to expand its AI-powered virtual specialty care platform and physician network aimed at filling specialty provider gaps and enhancing healthcare...
UniQure Gene Therapy Slows Huntington’s Disease Progression by 75%
UniQure announced positive topline results from its pivotal Phase I/II trial of AMT-130 gene therapy targeting Huntington’s disease, demonstrating a statistically significant 75% reduction in...
CRISPR Screens Reveal Genetic Enhancements for CAR T Cell Cancer Therapies
Researchers from Mass General Brigham and the Broad Institute utilized comprehensive CRISPR genetic screens to identify key gene knockouts that significantly improve CAR T cell proliferation,...
Bespoke Bacteriophage Therapies Tackle Antimicrobial-Resistant Superbugs
Monash University and The Alfred Hospital researchers have developed a tailored bacteriophage therapy cocktail, Entelli-02, specifically targeting antimicrobial-resistant pathogens. This...
FDA Initiates Approval of Leucovorin for Cerebral Folate Deficiency Amid Autism Debate
The FDA is advancing approval for leucovorin calcium tablets to treat cerebral folate deficiency (CFD), a neurological disorder linked to developmental delays and autistic features. This move...
Breakthrough CRISPR-Enhanced CAR T Therapies Show Promise Against Multiple Myeloma
Innovative studies reveal that targeted gene knockouts via CRISPR technology significantly enhance CAR T cell therapeutic efficacy in multiple myeloma models. These genetic alterations improve...
Smart Wearable Pad Detects Disease Biomarkers via Menstrual Blood
Researchers at ETH Zürich developed MenstruAI, a wearable sensor-integrated menstrual pad that detects disease-related molecules directly in menstrual blood via a colorimetric lateral flow assay....
UniQure’s Gene Therapy Shows Major Market Impact With FDA Filing Plans
Following a pivotal Phase I/II success demonstrating substantial slowing of Huntington’s disease, UniQure plans regulatory submission in early 2026, potentially marking the first approved gene...
Novel CRISPR-Enabled Screening Accelerates Genome Editing Efficiency
Recent advancements harness natural CRISPR-associated transposons (CASTs) to improve one-step, targetable genome editing with enhanced biomedical applicability. Screening methods have been...
AmplifyMD Raises $20M to Expand AI-Driven Virtual Specialty Care Platform
AmplifyMD secured a $20 million Series B funding round to scale its AI-powered virtual specialty care platform and physician network. Key investor and customer Memorial Hermann Health System...
Human Cell Atlas Identifies Fibroblast Subtypes With Therapeutic Targets
The Human Cell Atlas project mapped distinct fibroblast subpopulations in healthy and diseased skin via single-cell sequencing and spatial transcriptomics, uncovering six subtypes in normal tissue...
UniQure's Gene Therapy Slows Huntington’s Disease by 75%
UniQure has reported groundbreaking phase I/II trial results for its gene therapy AMT-130 targeting Huntington’s disease. The treatment achieved a 75% reduction in disease progression over three...
CRISPR Screening Enhances CAR-T Therapies for Multiple Myeloma
Researchers at Mass General Brigham and the Broad Institute have leveraged in vivo CRISPR screens to discover genetic modifications that improve the persistence and function of CAR T cells in...
FDA Initiates Approval of Leucovorin for Cerebral Folate Deficiency Affecting Autism
The FDA has begun the approval process for leucovorin calcium tablets as a treatment for cerebral folate deficiency (CFD), a neurological condition linked to developmental delays and autistic...