NIH’s All of Us research program has reached its target of collecting genetic and health-related data from one million Americans, the agency announced. The dataset aims to represent the country's demographic diversity, enabling broader population-level analyses and more equitable biomarker and drug-discovery research. Researchers and industry partners will use the cohort to support translational studies, real-world evidence generation, and diverse cohort recruitment for clinical trials. The milestone removes a long-standing sample-size barrier for many precision-medicine applications and could accelerate discovery of population-specific biomarkers and therapeutic targets.