Researchers at Colorado State University reported using artificial intelligence to redesign antibodies so they behave as fluorescent probes that reveal activity inside living cells, enabling visualization of gene‑expression errors linked to cancer and other disorders. The approach modifies antibody sequences to improve intracellular stability and signal while preserving target binding. The advance shortens probe development timelines and opens new possibilities for dynamic, live‑cell molecular imaging. Antibody‑based intracellular probes are engineered proteins that bind specific intracellular targets and report their presence or activity; AI here accelerates sequence optimization for cellular performance.