Researchers in David Baker’s lab released RFdiffusion3 as an open-source protein-design model capable of designing binders against DNA, small molecules and generating catalytic enzymes. The all-atom approach reportedly runs ten times faster than its predecessor and was demonstrated with experimental evidence for DNA-binding proteins and advanced enzyme designs in a bioRxiv preprint. Authors say RFdiffusion3’s atom-level control and speed broaden de novo design possibilities for therapeutics and sustainability applications. The lab framed the release as an invitation for the community to build on the model, accelerating translation of computational designs into experimental candidates.