A new workflow built around Seq‑Well enables scalable, low‑cost sample hashing for single‑cell multiomics, improving throughput for precious clinical samples. The method streamlines barcoding and pooling, reducing per‑sample cost while preserving multiomic readouts, and supports broader adoption of single‑cell profiling in translational studies. Developers validated the approach across diverse sample types and demonstrated robust demultiplexing and cell‑type recovery. The protocol emphasizes affordability and compatibility with existing lab infrastructure, targeting academic and clinical labs seeking to expand sample volume without sacrificing data complexity. The advance could accelerate biomarker discovery, patient stratification efforts, and pharmaceutical translational programs by lowering barriers to large‑cohort single‑cell studies. Commercial partners may package the workflow for regulated environments and scale manufacturing of reagents.