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AI Boosts Drug Discovery With Open-Source Model for Binding Affinity Prediction
Scientists at MIT and Recursion Pharmaceuticals launched Boltz-2, an AI-driven open-source platform that predicts small-molecule binding affinities with improved accuracy. This breakthrough...
CAR-T Therapy Targets Novel Solid Tumor Antigen for Enhanced Immunotherapy
Investigators at Nagoya University have engineered a novel CAR-T cell therapy directed against Eva1, a protein overexpressed in various solid tumors including lung, pancreatic, and liver cancers....
Next-Gen Genome Editing Targets Multiple Sites With Precision
Researchers are overcoming limitations in human gene editing by developing advanced tools capable of simultaneously modifying multiple genomic sites with enhanced accuracy. This innovation...
Regulatory Shake-Up: Entire CDC Vaccine Advisory Panel Dismissed
Health and Human Services Secretary Robert F. Kennedy Jr. removed all 17 members of the CDC's Advisory Committee on Immunization Practices (ACIP), citing conflicts of interest and intent to...
Metsera Advances Long-Acting Amylin Analog for Obesity Treatment
Metsera has reported encouraging early clinical data for its amylin analog, MET-233i, showing dose-dependent and sustained weight loss with potential for once-monthly dosing. These findings point...
Merck Launches Oral PCSK9 Inhibitor With Positive Phase III Dual Readouts
Merck & Co. announced successful Phase III results for its oral PCSK9 inhibitor, enlicitide decanoate, demonstrating significant reductions in LDL cholesterol across two key trials in patients...
Recursion Cuts 20% Workforce Amid Pipeline Narrowing
Recursion Pharmaceuticals announced layoffs affecting about 20% of its staff following a strategic pipeline cutback and focus on oncology and rare diseases after merging with Exscientia. The...
Predicting Viral Evolution Reveals Broad SARS-CoV-2 Antibodies
A novel computational framework integrating viral evolution modeling and immunology has identified broadly neutralizing antibodies against current and anticipated SARS-CoV-2 variants. This...
Merck’s Oral PCSK9 Inhibitor Clears Hurdle With Phase III Wins
Merck announced positive results from two phase III trials of its oral PCSK9 inhibitor, enlicitide decanoate, demonstrating significant reductions in LDL cholesterol in patients on statins with...
Merck’s Oral PCSK9 Inhibitor and Amylin Obesity Drug Poised For Market Impact
Merck reported promising Phase III data for its oral PCSK9 inhibitor enlicitide decanoate, showing significant LDL cholesterol reductions, aiming to capture a spot in a competitive market....
Immunotherapy and Electric Fields Combine To Extend Glioblastoma Survival
Researchers at Keck Medicine of USC demonstrated that Tumor Treating Fields (TTFields), which use alternating electric fields, combined with immunotherapy and chemotherapy, enhance T-cell...
CUTTING-EDGE COLLAGEN BIOPRINTING TECHNIQUE ADVANCES TISSUE ENGINEERING
A biomedical research team at Stony Brook University developed TRACE, a Tunable Rapid Assembly of Collagenous Elements method, enabling instant assembly and 3D bioprinting of physiological...
Revolutionary Rapid AI-Powered Viral Diagnostic Employs Nanopore Technology
Researchers unveiled a novel test using solid-state nanopores and machine learning to rapidly detect viral infections by analyzing unique electrical signals as viruses pass through nanoscale...
New Alzheimer’s Blood Test Gains FDA Clearance For Early Detection
Indiana University School of Medicine led the development of the first blood test approved by the FDA to detect amyloid plaques in the brain, a hallmark of Alzheimer's disease. The test offers a...
Proteomic Atlas Partnership Targets Alzheimer’s Biomarkers and Dementia Research
Alamar Biosciences partnered with the Alzheimer’s Disease Data Initiative and Gates Ventures to create a comprehensive plasma proteome atlas for Alzheimer’s and related dementias. The...
AI Innovations Accelerate Discovery In Complex Disease Genetics and Drug Development
Northwestern University researchers developed an AI-driven generative model capable of resolving gene combination patterns underlying complex diseases like diabetes and cancer, surpassing...
FDA Approves Merck’s RSV Antibody For Infant Use Amid Advisory Shakeup
The FDA granted approval to Merck's monoclonal antibody drug Enflonsia for preventing respiratory syncytial virus (RSV) infections in infants under 12 months. The drug is priced competitively...
Metsera’s Long-Acting Amylin Analog Shows Promising Obesity Trial Results
Metsera reported encouraging phase I data for its long-acting amylin analogue MET-233i, indicating dose-dependent weight loss efficacy and potential for once-monthly dosing. The therapy exhibited...
Merck's Oral PCSK9 Inhibitor Advances With Dual Phase III Success
Merck announced successful outcomes from two phase III studies evaluating its oral PCSK9 inhibitor, enlicitide decanoate, in patients with high cholesterol on statin therapy. The drug demonstrated...
Recursion Cuts 20% of Staff Following Pipeline Restructuring
Recursion Pharmaceuticals disclosed a 20% reduction in workforce following a recent decision to narrow its research focus and deprioritize multiple clinical-stage programs. This downsizing...