A team at HKUST unveiled the molecular mechanism by which human DICER processes precursor microRNAs with single‑nucleotide precision. The study mapped structural features and catalytic steps that enable DICER to generate exact miRNA termini, a process central to gene regulation. Findings were published by the researchers and carry implications for designing RNA‑based therapeutics and improving on‑target microRNA modulation. The work provides mechanistic insight relevant to cancer, immune disorders, and genetic diseases where miRNA processing is dysregulated, and it may inform more precise RNA‑interference and miRNA replacement strategies in drug discovery.