The Long Life Family Study selected PacBio’s Revio HiFi long‑read sequencing platform to generate genomic and epigenomic data from up to 7,800 participants to uncover genetic contributors to exceptional longevity. Investigators emphasized the technology’s ability to detect structural variants, repeat expansions and methylation patterns that short‑read approaches miss. Researchers plan to integrate high‑accuracy long reads with deep phenotyping across multigenerational pedigrees to map rare variants and epigenomic signatures linked to healthy aging. PacBio cited simplified workflows and methylation‑aware protocols as enabling comprehensive genome‑epigenome profiling at scale. The choice reflects a broader trend toward long‑read sequencing in population and aging genomics where complex structural variation and epigenetic marks are hypothesized to underlie phenotypes of extreme longevity.