Researchers unveiled HCS‑3DX, an AI‑driven high‑content screening platform for automated analysis of 3D multicellular structures such as spheroids and organoids, promising to speed drug discovery and personalized medicine workflows. The platform integrates imaging, automated handling and machine learning to characterize complex 3D models at scale. At ASHG, Atrandi Biosciences showcased semipermeable capsule technology enabling sequencing of RNA and DNA from single cells inside protective microcapsules, reporting collaborations that demonstrated the method’s applicability to single‑cell multiomic workflows. Combined, these technologies address bottlenecks in translating 3D and single‑cell models to actionable drug discovery data, improving throughput and reproducibility for target validation and phenotypic screening.