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Polymyxin B Antibiotic Discovered to Kill Bacteria via Energy-Dependent Membrane Disruption
Researchers from University College London and Imperial College London have elucidated the mechanism by which polymyxin B, a last-resort antibiotic against multidrug-resistant Gram-negative...
mRNA Vaccine Demonstrates Protection Against Macular Degeneration in Mouse Models
Scientists at the Institute of Science Tokyo have developed an intramuscularly delivered mRNA vaccine encoding LRG1 protein that inhibits pathological neovascularization in the retina, effectively...
AI-Enabled 3D Molecular Search Platform ROCS X Unlocks Trillions of Drug-Like Compounds
Cadence Molecular Sciences, collaborating with Treeline Biosciences, has launched ROCS X, an AI-enhanced virtual screening platform that conducts ultra-fast 3D searches on trillions of...
Advances in Radiation Therapy Show Parity and Patient Benefits in Cancer Treatments
Several landmark clinical trials have revealed significant findings in radiation oncology. A decade-long study demonstrated that stereotactic radiation matches surgery in long-term survival for...
Type V CRISPR Systems Emerged from Transposons via RNA Splitting Mechanism
A team led by Caixia Gao at the Chinese Academy of Sciences has uncovered the evolutionary origin of Type V CRISPR-Cas systems (Cas12 enzymes) revealing that functional RNA splitting events...
UniQure’s Gene Therapy Slows Huntington’s Disease Progression in Landmark Clinical Data
UniQure announced compelling 36-month clinical data from its AMT-130 gene therapy in Huntington’s disease showing a significant slowing of disease progression. High-dose patients achieved a 75%...
Nanoparticle-Enhanced Microelectrodes Advance Brain-Machine Interface Stability
A recent study has demonstrated that incorporating nanoparticles into intracortical microelectrodes significantly boosts their recording longevity and stability by attenuating the brain’s foreign...
Climb Bio’s CLYM116 Shows Promising Preclinical Profile for Treating IgA Nephropathy
Climb Bio presented new nonhuman primate data for CLYM116, a next-generation anti-APRIL monoclonal antibody designed for IgA nephropathy (IgAN). The preclinical study demonstrated a longer...
Innovative Anti-Cancer Research: Ligands Targeting Tumor Carbohydrates and Induced Mesenchymal Stem Cell Therapy
Researchers at University of California, Irvine have engineered lectin-based therapeutic proteins with a Velcro-like strong and highly specific binding to tumor-associated carbohydrate antigens....
Genmab Bolsters Pipeline: $8B Merus Buyout Targets Head and Neck Cancer
Genmab announced its acquisition of Dutch biotech Merus for approximately $8 billion in cash, securing rights to Merus’ bispecific antibody petosemtamab in late-stage development for head and neck...
Polymyxin B Mechanism Unveiled: Antibiotic Targets Active Bacteria Armor
In a revealing study published in Nature Microbiology, researchers from University College London and Imperial College London elucidated how polymyxin B, a last-resort antibiotic, disrupts...
Disrupting Glioblastoma: Biodegradable Scaffold Delivers TLR7/8 Agonist
Researchers have developed a novel biodegradable scaffold that locally delivers toll-like receptor 7/8 (TLR7/8) agonists, significantly improving immunotherapy efficacy against glioblastoma in...
RSV Vaccines Confirmed Safe and Effective in Large-Scale Reviews
Comprehensive analyses including a Cochrane systematic review encompassing over 100,000 participants have affirmed the safety and robust efficacy of respiratory syncytial virus (RSV) vaccines in...
uniQure's Gene Therapy Slows Huntington’s Disease Progression by 75%
uniQure reported groundbreaking 36-month clinical trial data demonstrating that its gene therapy candidate AMT-130 achieved a remarkable 75% slowing of Huntington’s disease progression at high...
FDA Reconsiders Surrogate Endpoints in Drug Approvals, CDER Director States
George Tidmarsh, director of the FDA’s Center for Drug Evaluation and Research (CDER), announced the agency’s intent to closely reevaluate the use of surrogate endpoints employed to accelerate...
AI-Powered Molecular Search Expands Chemical Space Trillions-Fold
Cadence Molecular Sciences has launched ROCS X, an AI-enabled virtual screening platform capable of conducting three-dimensional searches across trillions of drug-like molecules. Developed in...
Novel mRNA Vaccine Suppresses Neovascularization in Age-Related Macular Degeneration
Researchers at the Institute of Science Tokyo developed an mRNA vaccine that, when administered intramuscularly, effectively suppresses pathological retinal neovascularization in mouse models of...
Breakthrough in Simultaneous In Vitro Synthesis of All 21 tRNA Types
Researchers from the University of Tokyo and RIKEN Center for Biosystems Dynamics Research have pioneered a method enabling the simultaneous synthesis of all 21 transfer RNA species essential for...
Phase III Trial Shows Intensity-Modulated Radiotherapy and Proton Therapy Equivalent for Head and Neck Cancer
The TORPEdO Phase III clinical trial demonstrated that intensity-modulated radiation therapy (IMRT) and proton beam therapy (PBT) provide comparable patient-reported outcomes in the treatment of...
Genmab’s $8 Billion Merus Acquisition Sharpens Oncology Pipeline
Genmab is set to acquire Dutch biotech Merus for approximately $8 billion in cash, gaining full rights to a promising bispecific antibody targeting head and neck cancer. Merus’ petosemtamab drug...