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Lund University Antibody Restores Immune Attack on Leukemia Cells
Lund University researchers uncovered that acute myeloid leukemia (AML) cells express SLAMF6, an immune checkpoint protein enabling escape from T cell-mediated destruction. By engineering an...
Breakthroughs in Genetic and Molecular Oncology Diagnostics
Cutting-edge AI, genomic, and molecular diagnostic advances are reshaping cancer care. Transformer models combined with radiomic data now predict cervical cancer prognosis with enhanced accuracy....
Advances in RNAi Therapeutics and RNA Modifications in Cancer and Metabolism
Aerska, a biotech focusing on RNA interference, raised $21 million to develop antibody-oligo conjugates for delivering RNAi drugs across the blood-brain barrier targeting neurological diseases...
AstraZeneca and Algen Biotechnologies Join Forces on $555M AI Drug Discovery Pact
AstraZeneca has inked a $555 million agreement with San Francisco-based Algen Biotechnologies to harness Algen's AI-driven AlgenBrain platform targeting immunology drug discovery. The partnership...
Skye Bioscience's Obesity Drug Fails Phase 2, Combination Therapy Shows Promise
Skye Bioscience reported that its CB1 receptor inhibitor, nimacimab, did not achieve statistically significant weight loss in a mid-stage Phase 2a trial when used as monotherapy. The antibody...
Nobel Prize Honors Discoveries in Regulatory T Cells on Immune Tolerance
The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for seminal discoveries concerning regulatory T cells (Tregs) and their role in...
New Nanoparticle Therapy Reverses Alzheimer's in Mice by Restoring Blood-Brain Barrier
Researchers at the Institute for Bioengineering of Catalonia and West China Hospital Sichuan University have developed a bioactive nanoparticle therapy that reverses Alzheimer’s disease pathology...
Lund University Uncovers Leukemia Immune Escape Mechanism Targeted by Antibody
Lund University researchers have identified the SLAMF6 surface protein as an immune checkpoint mediating acute myeloid leukemia's (AML) evasion from immune attack. SLAMF6, expressed on AML stem...
International Clinical Trial Advances Prostate Cancer Treatment with Drug Combination
An international clinical trial led by University College London demonstrated that combining niraparib, a PARP inhibitor, with standard hormone therapies (abiraterone acetate and prednisone)...
FDA Initiates Pilot Program to Accelerate Generic Drug Approvals Using Domestic Sources
The US Food and Drug Administration announced a pilot program accelerating regulatory review for generic drugs manufactured domestically using US-sourced active pharmaceutical ingredients. This...
Asimov Commercializes Stable HEK293 Producer Cell Lines for Scalable AAV Gene Therapy Manufacturing
Asimov has launched its AAV Edge Stable Producer system, delivering clonal HEK293 stable cell lines that harbor essential viral genes for adeno-associated virus (AAV) vector manufacturing. These...
Insight Into Autoimmune Mechanisms in ALS Identifies Therapy Targets
New research published in Nature provides the first direct evidence of autoimmunity involvement in amyotrophic lateral sclerosis (ALS). Scientists discovered that CD4+ T helper cells in ALS...
TCG Crossover Closes $1.3 Billion Fund Targeting Biopharma Investments Amid Market Shifts
TCG Crossover (TCGX), a prominent life sciences investment firm, successfully closed its third fund at $1.3 billion, raising total capital to $3.1 billion across multiple funds. The firm aims to...
Nobel Prize Honors Regulatory T Cell Discoveries: Autoimmune Disease Insights
The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking work on regulatory T cells (T-regs). Their discoveries...
AstraZeneca and Algen Ink $555M AI Drug Discovery Deal in Immunology
AstraZeneca has entered a strategic partnership with San Francisco-based Algen Biotechnologies, agreeing to pay up to $555 million to leverage Algen's AI-driven AlgenBrain platform. This platform...
Skye Bioscience’s Obesity Drug Trial Fails Primary Endpoint, Combo Shows Promise
Skye Bioscience disclosed topline phase 2a data for Nimacimab, a peripherally restricted CB1 receptor inhibitor antibody targeting obesity. The monotherapy arm failed to meet its primary weight...
Nanoparticle Therapy Restores Blood-Brain Barrier, Reverses Alzheimer’s in Mice
A collaborative team led by the Institute for Bioengineering of Catalonia and West China Hospital developed bioactive supramolecular nanoparticles that modulate blood-brain barrier (BBB) transport...
Lund University Uncovers SLAMF6 Role in AML Immune Evasion, Antibody Restores T Cell Function
Researchers at Lund University identified a novel immune escape mechanism in acute myeloid leukemia (AML) involving the surface protein SLAMF6, expressed in approximately 60% of AML cases but...
Insilico Medicine Unveils AI Workflow LEGION to Explore Vast Drug Space and Protect Discoveries
Artificial intelligence-driven drug developer Insilico Medicine introduced LEGION, an AI workflow designed to exhaustively generate and cover chemical space around the NLRP3 inflammatory target,...
Asimov Launches Stable Producer Cell Lines to Scale AAV Gene Therapy Manufacturing
Asimov introduced its AAV Edge Stable Producer system, a platform generating stable HEK293 cell lines with integrated viral genes for adeno-associated virus (AAV) vector production, aiming to...