Get the Daily Brief
Latest Biotech News
CT-179: First-In-Class OLIG2 Inhibitor Enters Phase 1 Trials for Brain Tumors
Curtana Pharmaceuticals’ CT-179 is a novel, orally bioavailable small-molecule targeting OLIG2, a transcription factor driving brain tumor stem cells in glioblastoma and SHH-medulloblastoma. The...
Nobel Prize Awarded for Discovery of Regulatory T Cells in Immune Tolerance
The 2025 Nobel Prize in Physiology or Medicine honors Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for elucidating regulatory T cells (Tregs), a subset of CD4+ T lymphocytes critical for...
AstraZeneca and Algen Ink $555M AI-Powered Immunology Drug Discovery Deal
AstraZeneca has partnered with San Francisco-based Algen Biotechnologies in a $555 million collaboration leveraging Algen’s AlgenBrain platform, which combines single-cell CRISPR editing and...
MapLight Therapeutics Prepares $227M IPO Amid Government Shutdown Workaround
Neurological disease-focused biotech MapLight Therapeutics progressed plans for a $227 million Nasdaq initial public offering by employing a Securities Act provision allowing registration...
Nobel Prize Awarded for Regulatory T Cell Discovery – Advances Autoimmune Disease Understanding
The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries on regulatory T cells (Tregs). These...
Eli Lilly Appoints Former FDA Official Peter Marks – Strengthens Infectious Disease and Discovery Efforts
Peter Marks, former head of the FDA's Center for Biologics Evaluation and Research (CBER), has joined Eli Lilly as senior vice president of molecule discovery and head of infectious disease. Marks...
Skye Bioscience's CB1 Inhibitor Fails Phase 2 Weight Loss Trial – Combination Therapy Shows Promise
Skye Bioscience announced that nimacimab, its peripheral cannabinoid receptor 1 (CB1) inhibitor antibody, failed to produce significant weight loss as monotherapy in a 26-week phase 2a trial....
Arbor Biotechnologies and Chiesi Group Forge $2B+ Partnership for Rare Disease Gene Editing
Italian pharmaceutical company Chiesi Group has secured exclusive global rights to Archer Biotechnologies’ ABO-101 gene editing therapy for primary hyperoxaluria type 1 (PH1), an ultra-rare kidney...
Mytos Launches Automated CDMO Facility to Scale Stem Cell Therapy Manufacturing in UK
Mytos, a UK-based cell therapy manufacturing company, has inaugurated its first automated contract development and manufacturing organization (CDMO) facility located within the Cell and Gene...
Insilico Medicine Advances AI Workflow LEGION – Drug Discovery and Intellectual Property Strategy
Insilico Medicine researchers introduced LEGION, a hybrid artificial intelligence workflow combining mechanistic modeling with deep learning, designed to significantly expand chemical space...
Twist Bioscience and Element Biosciences Expand Partnership for Targeted Sequencing Solutions
Twist Bioscience and Element Biosciences extended their collaboration to develop targeted sequencing solutions optimized for Element's AVITI platform. The partnership includes releasing Twist’s...
Aerska Emerges with $21Million Seed Funding to Advance RNAi Therapies for Neurological Diseases
Dublin-based biotechnology startup Aerska has announced a $21 million seed financing led by Age1, Backed VC, and Speedinvest to develop RNA interference (RNAi) therapeutics targeting neurological...
Moffitt Cancer Center Receives $22.4 Million Grant to Study Leptomeningeal Disease
Moffitt Cancer Center has secured a $22.4 million grant from the U.S. Department of War dedicated to research and clinical trials on leptomeningeal disease, a serious complication from cancer...
2025 Nobel Prize Recognizes Immune System Tolerance Breakthrough
The 2025 Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their discovery of regulatory T cells (Tregs), a critical mechanism of...
MapLight Advances IPO Attempts Amid SEC Shutdown
MapLight Therapeutics, developing CNS-targeted drugs including a schizophrenia medication poised to compete with Bristol Myers Squibb's Cobenfy, is pushing forward with IPO plans amid a U.S....
AI Accelerates Drug Discovery While Blocking Competition
Insilico Medicine unveiled LEGION, an AI-driven drug discovery workflow covering vast chemical space around the NLRP3 inflammation target. This platform seeks to optimize new compound...
Aerska Secures $21 Million to Advance RNAi CNS Therapeutics
Dublin-based Aerska, focused on RNA interference therapeutics for neurological diseases, raised $21 million in a seed financing round. The company’s antibody-oligonucleotide conjugate platform...
Trogenix Raises $95M Series A to Launch Glioblastoma Trials
Trogenix Ltd., emerging from stealth mode, secured $95 million in Series A funding to propel its pipeline into clinical trials, focusing on a novel “Trojan horse” gene therapy approach targeting...
Golden Helix Wins NIH Grants to Enhance Pharmacogenomics Software
Bioinformatics company Golden Helix received a $2.2 million NIH Phase II SBIR grant to advance its VSPGx pharmacogenomics interpretation software. The platform analyzes next-generation sequencing...
Novel Alzheimer’s Blood Test Gains FDA Clearance
Fujirebio Diagnostics obtained FDA clearance for the Lumipulse® G pTau 217/β-Amyloid 1-42 Plasma Ratio Test, the first blood-based FDA-approved in vitro diagnostic for Alzheimer’s disease. This...