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Latest Biotech News

Nanobiotix gets royalty loan; Tubulis upsizes Series C to $401M

November 01, 2025

Nanobiotix secured $71 million in non‑dilutive financing from HealthCare Royalty to support the late‑stage development of its radiotherapy‑activated nanotherapy partnered with Johnson & Johnson....

Lilly’s tirzepatide soars — Novo’s new CEO doubles down on M&A

November 01, 2025

Eli Lilly reported tirzepatide (Mounjaro/Zepbound) sales exceeding $10 billion for the third quarter, prompting the company to raise revenue guidance. The blockbuster performance cements...

Human kidney organoids integrated with pig kidneys... scalable transplant step

November 01, 2025

Researchers demonstrated a scalable pipeline to produce thousands of human kidney organoids and integrate them into ex vivo perfused porcine kidneys, then perform the first transplants of porcine...

Nanoparticle IL‑12 therapy revives ovarian immunotherapy responses

November 01, 2025

MIT teams published preclinical data showing polymer‑coated nanoparticles that deliver IL‑12 directly to ovarian tumors can convert immunologically cold lesions into responsive ones and, when...

Gene therapy milestone for ADA‑SCID... Baby KJ roadmap published

November 01, 2025

A joint UCL–UCLA gene therapy program reported multi‑year follow‑up data showing a gene therapy for ADA‑SCID restored immune function in treated children with a 95% success rate and no major...

Metsera takeover fight: Novo tops Pfizer with higher bid, legal clash ensues

November 01, 2025

Novo Nordisk submitted a higher unsolicited offer for obesity biotech Metsera, prompting an immediate legal and strategic response from Pfizer. Novo’s bid raises the deal value well above Pfizer’s...

Intellia CRISPR trials halted: FDA places formal hold after liver toxicity case

November 01, 2025

The FDA placed a clinical hold on two Phase 3 trials of Intellia Therapeutics’ CRISPR candidate nexiguran ziclumeran after a participant experienced severe liver enzyme elevations and...

Human kidney organoids scaled and integrated into pig kidneys...first in‑vivo transplant milestone

November 01, 2025

Researchers developed a scalable method to produce thousands of human kidney organoids and demonstrated integration with perfused porcine kidneys ex vivo, culminating in the first transplant of...

AI accelerates drug discovery and cell modeling: Google proposes a cancer drug; CZI and NVIDIA scale virtual cells

November 01, 2025

Google unveiled an AI-led discovery claiming a validated new cancer drug combination generated by its Cell2Sentence-Scale model family, signaling rapid advances in foundation models applied to...

Heritable genome editing and bespoke CRISPR: startups form and clinicians publish FDA playbook

November 01, 2025

A wave of ventures pursuing heritable genome editing emerged, with one U.S. entrepreneur raising significant early funding to study the ethics and feasibility of gene-edited embryos. At the same...

Tumor resistance mechanisms: Myeloid IFNγ signaling and copy-number changes undermine immunotherapy

November 01, 2025

Dana-Farber researchers identified interferon‑gamma signaling within tumor-associated myeloid cells as a driver of resistance to immune checkpoint inhibitors in renal cell carcinoma, revealing a...

Localized cytokine delivery: IL‑12 nanoparticles revive ovarian tumor immunity in preclinical models

November 01, 2025

MIT and collaborators engineered polymer-coated nanoparticles that deliver IL‑12 directly to ovarian tumors and demonstrated robust antitumor responses when combined with checkpoint inhibitors. In...

Lilly commercial moves and tirzepatide momentum: retail pickup and blockbuster sales

November 01, 2025

Eli Lilly expanded distribution for its GLP‑1 tirzepatide obesity drug Zepbound by enabling retail pharmacy pick-up at Walmart through its LillyDirect platform, broadening access beyond home...

Diagnostics market expands: Guardant scales multi‑cancer blood screening as FDA clearances proliferate

November 01, 2025

Guardant Health launched its Shield multi‑cancer detection (MCD) test into broader clinical use and signaled plans to gather real‑world adoption data for multi-cancer screening, while Diasorin...

Funding and PE activity: Tubulis upsizes Series C; GHO Capital closes largest European healthcare PE fund

November 01, 2025

ADC developer Tubulis expanded its Series C to $401 million to accelerate proprietary antibody‑drug conjugate programs, reflecting investor appetite for differentiated oncology platforms....

Metsera M&A War: Novo Nordisk Counters Pfizer With $9B Bid

October 31, 2025

Novo Nordisk launched a surprise unsolicited bid for Metsera that outvalues Pfizer’s previously agreed acquisition, setting off a rapid escalation in the obesity M&A sweepstakes. Novo offered...

FDA Halts Intellia Phase‑3 CRISPR Trials: Liver Safety Signal

October 31, 2025

Regulators put two late‑stage clinical trials of Intellia Therapeutics’ CRISPR therapy nexiguran ziclumeran on formal hold after a participant developed severe liver injury, deepening scrutiny of...

Human kidney organoids scaled: Transplanted into perfused pig kidneys

October 31, 2025

Teams led by the Institute for Bioengineering of Catalonia and collaborators reported a reproducible, scalable method to generate thousands of human kidney organoids and successfully integrate...

Targeted immunotherapy advances: IL‑12 nanoparticles and myeloid resistance mechanisms

October 31, 2025

Two preclinical findings offer complementary routes to improve checkpoint immunotherapy. MIT engineers reported polymer‑coated nanoparticles that deliver IL‑12 directly into ovarian tumors; in...

AI accelerates discovery: Google finds drug lead; CZI and NVIDIA scale virtual cell models

October 31, 2025

AI is moving from hypothesis generation toward actionable biomedical outputs. Google announced a large foundation model that proposed a novel cancer drug combination which the company validated...