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Pfizer obesity program adds monthly dosing evidence
Pfizer broadened the clinical case for its monthly obesity GLP-1 treatment berobenatide with new mid-stage data on a weekly-to-monthly dosing path. The company’s data were presented at the...
Roche moves into combination obesity trial planning
Roche said it plans to start a Phase 2 trial this year testing an obesity-drug combination of petrelintide and enicepatide. The company framed the pairing as an opportunity to combine a...
Abivax UC trial results spark cancer-signal overhang
Abivax’s shares swung after the company’s Phase 3 ABTECT maintenance trial posted positive topline results for obefazimod in ulcerative colitis, but investors focused on malignancies seen in...
ERAP1 inhibitor plus PD-1 blockade expands in anti-PD-1 resistance
GRWD5769, an oral ERAP1 inhibitor, combined with cemiplimab showed durable activity across multiple Phase 1b expansion cohorts in solid tumors with secondary anti–PD-1 resistance and in MSS-CRC....
Pfizer monthly shot effectiveness in obesity with diabetes
Pfizer presented data indicating berobenatide’s long-acting monthly GLP-1 regimen delivers efficacy in patients with both obesity and diabetes, reinforcing the drug’s positioning after its Metsera...
Biosafety: home dental care gaps tied to systemic disease in homebound elderly
A German observational analysis using health insurance claims data linked discontinuation of dental care to worsening systemic diseases in homebound elderly patients. Published under the InSEMaP...
Diagnostics: CRISPR assay targets field detection of mpox
Researchers engineered a portable CRISPR-based assay for mpox detection designed for field use following the 2025 outbreak in Sierra Leone. The work, led by Gopal, Abay, and Payne, aims to improve...
Seizure-targeted ADC enters first-in-human testing
ABBV-706, a SEZ6-targeting antibody-drug conjugate, began first-in-human evaluation in patients with advanced solid tumors. The clinical update is logged in a Journal of Clinical Oncology...
Oral cancer risk monitoring: saliva test links oral precancer to outcomes
A new saliva-based biomarker strategy is being advanced for oral potentially malignant disorders, with reported links between oral precancer status and clinical outcomes. The study, led by Chen...
Obesity drugs: new efficacy and discontinuation data
Boehringer Ingelheim’s obesity shot, survodutide (licensed from Zealand Pharma), saw notable Phase 3 discontinuations attributed to side effects, according to SYNCHRONIZE-1 reporting referenced in...
Obesity pipeline: retatrutide safety/tolerability details
Eli Lilly disclosed additional safety and tolerability data for retatrutide at the American Diabetes Association meeting, including counts of arrhythmias and major cardiovascular complications...
Obesity competition: Roche obesity combo trial starting
Roche plans to initiate a Phase 2 trial combining petrelintide and enicepatide later this year, according to ADA26 reporting. The companies are positioning the dual-incretin approach as a path to...
Obesity competition: Pfizer monthly berobenatide data
Pfizer presented updated clinical data supporting monthly dosing of berobenatide for obesity, following earlier signals from VESPER-3. In the study, patients transitioned from weekly dosing to...
Obesity pipeline validation: Pfizer’s berobenatide in obesity and diabetes
At ADA26, Pfizer added additional framing for berobenatide’s use in obesity and diabetes, citing data presented alongside its long-acting GLP-1 receptor agonist program. The coverage also ties the...
Company finance: Ona raises $86.6M
Ona secured an $86.6 million venture round positioned among Spain’s largest biotech financings, according to Biocentury Finance reporting. The capital injection underscores continued appetite for...
M&A/strategy: Forbion brings in Novo business development leader
Forbion announced the hire of John McDonald as an operating partner focused on business development and M&A, with prior experience including corporate business development leadership at Novo...
Oncology tools: first-in-human ADC development expands
An early first-in-human study is underway for ABBV-706, a SEZ6-targeting antibody-drug conjugate (ADC), in patients with advanced solid tumors. The program’s Journal of Clinical Oncology...
ADC pipeline: SYS6043 Phase 1 dose escalation
SYS6043, a B7-H3/Top1 antibody-drug conjugate (ADC), began Phase 1 dose escalation in solid tumor malignancies, according to the study listing. The start of dose escalation highlights ongoing...
Diagnostics & infectious disease: portable CRISPR assay for mpox
Researchers engineered a portable CRISPR-based assay for mpox detection in the wake of the 2025 outbreak in Sierra Leone, as described in the report. The approach is aimed at field diagnostics and...
Obesity pharmacology: new retatrutide safety/tolerability updates
Eli Lilly disclosed additional safety and tolerability data for retatrutide at the American Diabetes Association meeting and in The Lancet, extending results from TRANSCEND-T2D-1. The company...