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HHS pares pediatric schedule—industry raises alarms
U.S. health officials revised the federal childhood immunization schedule, narrowing routine recommendations and moving several vaccines to risk‑based or shared‑decision categories. The Centers...
OpenAI rolls ChatGPT Health—seeks richer health data
OpenAI launched ChatGPT Health, a dedicated offering for health-related conversations designed to help users navigate personal health information rather than provide diagnoses. The company invited...
Rakuten raises $100M—pushes photoimmunotherapy toward FDA filing
Rakuten Medical closed a $100 million financing round to support its photoimmunotherapy platform and an ongoing Phase III trial, with company statements indicating a targeted regulatory filing...
NGS and multiomic tools advance—MD Anderson, Sophia; Illumina software
Sophia Genetics and MD Anderson announced a collaboration to co‑develop an NGS‑based oncology assay and AI-driven bioinformatics pipelines to interpret RNA‑seq and multiomic cancer data, with the...
Lilly pays $1.2B for Ventyx: adds oral NLRP3 program
Eli Lilly agreed to buy Ventyx Biosciences for $1.2 billion to add an oral NLRP3 inhibitor to its inflammation and metabolic portfolio. Ventyx’s lead candidate, VTX3232, showed biomarker and...
GSK, Ionis: bepirovirsen hits functional cure endpoints – filings planned
GSK and development partner Ionis reported positive top-line results from two pivotal Phase 3 studies of bepirovirsen, an antisense oligonucleotide aimed at functional cure for chronic hepatitis...
Amgen spends up to $1.46B – buys Dark Blue, licenses Disco target
Amgen struck multiple European deals to bolster its oncology pipeline, including an acquisition of Dark Blue Therapeutics and a license from Disco Pharmaceuticals. The transactions total up to...
Alumis’ TYK2 pill clears Phase 3 – stock surges
Alumis reported positive Phase 3 results for envudeucitinib, a selective oral TYK2 inhibitor, meeting co‑primary endpoints in two pivotal psoriasis studies. The company said the trials showed high...
Arrowhead RNAi shows fat loss with tirzepatide combo – adipose proof of concept
Arrowhead Pharmaceuticals disclosed early clinical signals from RNAi programs targeting adipose biology that, when paired with Lilly’s tirzepatide (Zepbound), produced larger fat and weight...
Sanofi inks up‑to‑$2.56B Earendil deal: AI‑designed bispecifics
Sanofi signed a multi‑year collaboration with Earendil Labs valued up to $2.56 billion to discover bispecific antibodies for autoimmune diseases using Earendil’s AI platform. The pact includes...
BNCT preserves immune cells; engineered OMVs amplify CAR‑T in solid tumors
Two preclinical immuno‑oncology advances surfaced this week. A Nature Communications study showed Boron Neutron Capture Therapy (BNCT) can preserve immune cell integrity while eliciting anti‑tumor...
CNS and ocular gene‑therapy moves: non‑addictive pain therapy and intravitreal delivery pact
Academic and industry groups reported gene‑therapy advances in two distinct domains. University of Pennsylvania researchers published in Nature a cortical gene‑therapy approach that mimics opioid...
AI drug discovery: Insilico‑Servier oncology pact and 1910’s PEGASUS model
AI‑driven discovery activity accelerated with two notable developments. Insilico Medicine signed an $888 million collaboration with Servier to discover oncology candidates using its AI platforms....
CDC trims childhood vaccine schedule: industry warns of risks
Federal health authorities moved to reduce the number of routinely recommended childhood vaccines, shifting several shots to targeted or shared‑decision categories. The change—announced by HHS and...
GSK, Ionis claim Phase 3 success – filings planned
GSK and Ionis announced positive topline results from two pivotal Phase 3 trials (B‑Well 1 and B‑Well 2) of bepirovirsen, an antisense oligonucleotide designed to drive functional cures in chronic...
GSK taps Helix’s GenoSphere: clinico‑genomic data deal
GSK struck a multi‑year strategic collaboration with Helix to access GenoSphere, Helix’s clinico‑genomic database of whole‑exome sequencing linked to longitudinal medical, pharmacy and mortality...
Alumis’ TYK2 pill clears Phase 3: approval push begins
Alumis reported that envudeucitinib, its oral TYK2 inhibitor, met primary and key secondary endpoints across two Phase 3 trials in moderate‑to‑severe plaque psoriasis. The company said results...
Amgen buys Dark Blue – $840M deal for targeted degrader
Amgen agreed to acquire U.K. oncology startup Dark Blue Therapeutics in a deal worth up to $840 million, gaining preclinical programs focused on protein degraders for acute myeloid leukemia and...
Sanofi inks $2.56B AI bispecific deal with Earendil
Sanofi signed a discovery and development collaboration with AI‑driven Earendil Labs focused on bispecific antibodies for autoimmune and inflammatory diseases, a pact valued up to $2.56 billion....
Lilly returns to Nimbus: $55M upfront for oral obesity program
Eli Lilly extended its collaboration with Nimbus Therapeutics to develop an oral obesity therapy, committing $55 million in upfront and near‑term payments and potential downstream milestones that...