Researchers published the most comprehensive physiological and multiomic dataset to date from a pig-to-human kidney transplant conducted in a brain-dead recipient, tracking the graft and host responses over a 61‑day period. Two Nature papers—one focused on physiological/immunological measures and the other on multiomic profiling—detailed the molecular and cellular drivers of rejection and graft adaptation. The studies reported temporal immune activation signatures, tissue-level responses, and multiomic correlates that reveal mechanisms of innate and adaptive rejection against genetically modified pig organs. The datasets function as an 'encyclopedia' to guide genetic editing, immunosuppression strategies, and biomarker development for clinical xenotransplantation. Authors framed the work as a translational bridge: the long-duration, deeply phenotyped experiment provides mechanistic targets for reducing rejection and informs risk assessment for future human trials of engineered xenografts.