Researchers at The Wistar Institute published nonhuman primate data showing a vaccine candidate elicited neutralizing antibodies after a single immunization. The work, appearing in Nature Immunology, claims the first example of single‑shot induction of neutralizing responses in primates and suggests a potential path to shorter immunization regimens for HIV. The study advances antigen and delivery engineering approaches and will require follow‑up in diverse animal models and early clinical testing. If translatable to humans, single‑shot HIV strategies could simplify logistics and broaden vaccine access, but clinical validation remains the critical next step.