Teams from Columbia, Stanford, Penn and NewYork‑Presbyterian reported an ultra‑high‑density, wireless subdural brain‑computer interface integrating 65,536 electrodes and 1,024 recording channels on a single 50 μm‑thin silicon substrate. Preclinical studies in pigs and nonhuman primates demonstrated chronic recordings and decoding of motor and sensory features. Authors including Ken Shepard and Nanyu Zeng framed the Biological Interface System to Cortex (BISC) as a low‑profile implant that fits between skull and brain, offering high spatiotemporal resolution without bulky skull canisters. The design integrates wireless power and telemetry and was published in Nature Electronics, positioning semiconductor scaling as a route to clinically translatable BCIs. The advance raises considerations for clinical translation—surgical approach, biocompatibility, data throughput, regulatory pathways and commercialization models—as neurotech and med‑tech players evaluate next steps toward human trials and productization.