Researchers published a validated workflow enabling robust whole‑genome sequencing (WGS) from formalin‑fixed, paraffin‑embedded (FFPE) tumor specimens, overcoming longstanding technical hurdles. The new methodology increases usable genomic yield from archival clinical samples and promises to broaden access to comprehensive genomic profiling in routine oncology practice. Clinical labs and trial sponsors can leverage FFPE‑compatible WGS to characterize tumor mutational landscapes retrospectively and prospectively, enhancing biomarker discovery, patient selection and real‑world evidence generation.