Researchers published a methodology enabling robust whole‑genome sequencing (WGS) from formalin‑fixed, paraffin‑embedded (FFPE) tissue, overcoming long-standing technical challenges in archival specimen genomics. The advance allows clinically relevant genomic profiling from routine pathology blocks that previously yielded degraded DNA. The paper details optimized extraction, library prep and bioinformatic pipelines that reduce artifacts and increase coverage uniformity, expanding the utility of existing clinical samples for comprehensive genomic analyses. This has direct implications for tumor profiling, biomarker discovery and retrospective cohort studies where FFPE is the only available material. Clinical sequencing labs and pharma translational groups can apply the protocol to accelerate target identification and patient matching, but analytical validation and regulatory alignment for diagnostic use will be required.