Researchers developed a robust workflow enabling whole-genome sequencing (WGS) from formalin-fixed paraffin-embedded (FFPE) tissue specimens, overcoming historical limitations of DNA damage and chemical modification. The advance enables comprehensive genomic profiling from routine clinical pathology archives, expanding access to retrospective cohorts and biomarker discovery in oncology. The technique improves variant calling and structural‑variant detection from archived samples, which could accelerate discovery of actionable mutations and support precision medicine in settings where fresh frozen tissue is unavailable. Adoption will hinge on reproducibility across pathology workflows and integration with clinical-grade bioinformatics pipelines. FFPE denotes formalin-fixed, paraffin-embedded tissue — the standard method for long-term histopathology sample storage that historically complicated high-quality genomic analysis.