Harvard Medical School researchers published a virome-wide ubiquitin ligase discovery effort that maps diverse viral immune-evasion strategies by scaling up functional protein screens. Using ORFeome, the team generated a library of roughly 13,000 DNA constructs encoding about 9,000 proteins from 513 viruses. The work, detailed in Science, links viral proteins to how they hijack host “garbage-disposal” pathways, using a genetic barcode approach to study thousands of viral open reading frames in pooled cell experiments. The library is intended to shift virology from studying one virus or one family at a time toward identifying shared strategies across the viral world. The researchers said they will make the ORFeome freely available, aiming to accelerate discovery that could inform vaccine and therapeutic target selection for emerging pathogens.