Wistar Institute scientists reported a single‑shot HIV vaccine candidate that elicited neutralizing antibodies in nonhuman primates, marking a notable preclinical advance published in Nature Immunology. The finding challenges expectations about prime‑boost paradigms and opens a potential path toward simplified immunization strategies for HIV. Separately, Baylor College of Medicine described a robust method to continuously cultivate human norovirus in vitro, enabling extended laboratory study of the leading cause of viral gastroenteritis. Continuous culture of human norovirus removes a longstanding experimental barrier and should accelerate antiviral screening and pathogenesis research.