A novel method developed by Boston Children's Hospital and Harvard Medical School allows the rapid creation of functional vascular organoids from human stem cells by co-activating endothelial and mural cell transcription factors ETV2 and NKX3.1. The organoids self-assemble and form perfusable vessels upon transplantation, offering a scalable platform for vascular biology research, tissue engineering, and regenerative medicine applications with improved control over vascular lineage development.