The US government shutdown commencing October 1, 2025, poses significant challenges for the scientific community. Key science agencies, including the NIH and NSF, have halted non-essential operations, suspending research activities and grant awards. Concerns loom over potential layoffs of federal scientific personnel and disruptions in ongoing clinical trials and regulatory processes. The shutdown's duration remains uncertain but threatens to impede scientific progress, particularly in biomedical research, where stability and funding continuity are critical for innovation and patient advancement.