Researchers have created the largest genetic map of human metabolism to date by analyzing data from approximately 450,000 UK Biobank participants across multiple ancestries. Published in Nature Genetics, the study integrates metabolic and genomic information to identify nearly 30,000 metabolite-locus associations across 753 regions, elucidating genetic regulation of blood metabolites and lipid traits. This extensive map offers new insights into genetic determinants of metabolism and disease predisposition, facilitating identification of therapeutic targets and advancing personalized medicine.