The U.S. Centers for Disease Control and Prevention (CDC) is undergoing significant leadership turmoil following the White House's ouster of CDC Director Susan Monarez, amid reports of disagreements and censorship of scientific communication. Several top CDC officials resigned, citing concerns regarding politicization and weaponization of public health. Concurrently, FDA imposed more restrictive approvals on COVID-19 vaccines paralleling these administrative changes. This unprecedented upheaval raises concerns about the continuity of pandemic preparedness, biosecurity, and public health policy enforcement in the country.