A UC San Diego team reported methods to improve yeast performance as biofactories for complex plant compounds by optimizing cytochrome P450 function and coordinating metabolic activity across organelles. The paired studies described enzyme engineering and systems‑level interventions that raised production efficiency and stability for target plant metabolites used in agriculture and specialty chemicals. Researchers emphasized that improving P450 activity and intracellular coordination can reduce bottlenecks in heterologous pathways. The advancement could lower costs and scale manufacturing of plant‑derived molecules for crop protection, fragrances and nutraceuticals, accelerating industry adoption of sustainable bioproduction.