Researchers at the University of British Columbia achieved a first-in-human transplant of a kidney enzymatically converted from type A to universal type O blood group. This enzymatic treatment removes antigenic sugars that cause blood group incompatibility, potentially increasing organ availability for transplantation. In the trial, a converted kidney functioned without hyperacute rejection for two days, with only mild immune reactions developing thereafter. This marks a milestone in addressing the shortage of compatible donor organs and offers a new approach to organ compatibility issues.