Lead: Two complementary reports from Ma et al. used transcriptome‑wide association study (TWAS) methods to nominate novel causal genes linked to diabetic nephropathy, expanding the genetic map of a leading cause of kidney failure. The analyses integrated GWAS summary statistics with tissue‑specific expression reference panels to implicate functional candidates. Authors highlighted several genes not previously connected to diabetic kidney disease, presenting colocalization and Mendelian randomization evidence to support causality. The studies named the kidney and relevant metabolic tissues as loci of effect and prioritized genes for experimental follow-up. The work provides a prioritized gene list for target validation and biomarker development; translational teams and drug developers may use these candidates to design functional screens, small‑molecule programs, or repurposing strategies aimed at slowing diabetic renal decline.