Researchers reported an AI-guided approach to rapidly identify thermostable mRNA–lipid nanoparticle vaccine formulations, addressing a key barrier to global distribution of mRNA platforms. Using an algorithm termed AGENT (Algorithm-Guided Experimental design for lipid Nanoparticle Thermostabilization), the team completed formulation optimization in six iterations over roughly one month and achieved solid-state formulations that preserved 100% bioactivity after storage at 37°C for more than two months.