A study published in the Journal of Translational Medicine reveals that targeting soluble epoxide hydrolase (sEH) can modulate M1 macrophage polarization and ease symptoms in temporomandibular joint (TMJ) osteoarthritis. This discovery opens new avenues for therapeutic interventions addressing inflammatory joint disorders that affect millions worldwide. The findings highlight sEH as a promising molecular target to control immune responses and tissue degradation in TMJ osteoarthritis.