Advances in organ transplantation leverage single-cell techniques, artificial intelligence, and novel therapeutics to enhance graft survival and transplant outcomes. Single-cell sequencing elucidates kidney transplant biology and tissue spatial dynamics (ab8df21c02d8e393). AI-driven models optimize organ allocation using gradient boosting and genetic algorithms (2b49e92af6665b95). Additionally, injectable cytokine-loaded cryogels enable in situ reprogramming of tumor-associated macrophages to bolster immunotherapies (e593d9fc80ae4d62). Research into regenerative hydrogel materials mimicking embryonic environments shows promise in stem cell therapies, potentially revolutionizing tissue repair.