A review explored targeted protein degradation (TPD) as a transformative therapeutic modality while flagging potential broader biological and ecological impacts. Authors (Yue, He, Hou et al.) summarized methods such as PROTACs and molecular glues, cataloged disease targets, and discussed off‑target degradation risks that could affect non‑human species if environmental exposure occurs. The paper calls for integrated safety assessment frameworks across human health and environmental domains during TPD development. Clarification: TPD technologies recruit cellular disposal systems to selectively eliminate disease‑causing proteins rather than inhibit them.