Tagomics published a methods paper in Cell Reports Methods describing Active‑Seq, an enzymatic, methyltransferase‑directed tagging and enrichment approach that profiles unmodified (unmethylated) DNA without base conversion. The Activace workflow is optimized for low‑input cell‑free DNA and supports discovery of hypomethylated and hypermethylated regions in colorectal cancer cohorts. The method bypasses challenges of bisulfite conversion in liquid biopsy and claims compatibility with 1 ng inputs, offering a scalable path for tissue‑of‑origin deconvolution and biomarker discovery in cfDNA. The publication establishes technical validation and sets the stage for translational applications in cancer diagnostics and monitoring.