Synthetic biology continues to offer innovative solutions for environmental and biomedical challenges. Researchers have engineered bacteria capable of degrading tetracycline antibiotics, addressing eco-toxicology concerns, while enzymatic systems efficiently tackle polyester in plastics recycling, contributing to circular economy goals. Bio-inspired sweat sensors with self-cleaning properties enhance wearable health monitoring technologies. Advances in genome synthesis and editing facilitate the redesign of staple crop genomes to improve agricultural sustainability. These developments showcase the convergence of biotechnology and environmental stewardship in novel applications with far-reaching impacts.