Researchers revealed structural mechanisms bacteria use to control ribonucleotide reductase (RNR) expression, identifying the transcriptional regulator NrdR as a bacteria‑specific node for controlling dNTP pools. The work—reported in a detailed structural and mechanistic analysis—positions NrdR as a selective antimicrobial target because it lacks eukaryotic homologs. The studies combined biochemistry, cryo-EM and genetics to show how NrdR senses nucleotide levels and modulates RNR expression, clarifying a central bacterial vulnerability in DNA synthesis control. Authors and commentators say the target could enable narrow‑spectrum agents that limit collateral damage to host cells and the microbiome. Translational steps will require small‑molecule tool development and validation in infection models, but the mechanistic clarity provides a clear pathway for next‑generation antibiotics that act via transcriptional control of DNA precursor synthesis.