Innovations in regenerative medicine highlight stem cell therapies as promising options for female reproductive disorders. Reviews and studies by Nair et al. and others elucidate their potential in treating infertility and premature ovarian failure, demonstrating capabilities to restore ovarian function and improve fertility outcomes. Additionally, investigations into umbilical cord mesenchymal stem cells combined with melatonin suggest novel therapeutic avenues for ovarian rejuvenation and premature ovarian failure management.