Researchers at Harvard’s Wyss Institute developed a novel stem cell differentiation method that directly induces meiosis in human induced pluripotent stem cells, circumventing previous barriers linked to the primordial germ cell state. This protocol enables in vitro modeling of human gametogenesis to better understand infertility mechanisms and develop drug discovery platforms. Geneticist George Church highlighted the potential to eventually model and correct meiotic defects leading to infertility. The method offers promising avenues for accessible fertility treatments addressing a critical global health need.