Researchers announced new ‘immune-evasive’ donor DNA formats that permit safe, non-viral insertion of kilobase-scale payloads in vivo, addressing a major hurdle for scalable gene writing. Teams described circular single-stranded DNA donors and ‘‘stealth’ DNA circles that avoid triggering cytosolic DNA sensors such as cGAS while retaining compatibility with recombinase-based integration. In mouse liver models these donors supported large-payload integration after lipid nanoparticle delivery, producing therapeutic expression without the fatal immune reactions seen with conventional double-stranded donors. Papers and preprints detail the molecular design choices—short dsDNA integration handles and circularization—to balance recombinase recognition with immune evasion.