St. Jude Children’s Research Hospital published a new method to better detect small off‑target changes produced by base editors, addressing a key safety challenge in precision genome editing. The technique improves sensitivity for identifying low‑frequency off‑target edits that can pose safety risks in therapeutic contexts, allowing researchers and developers to prioritize engineering efforts and safety mitigations. St. Jude positioned the approach as a practical tool to accelerate preclinical safety evaluation and reduce time and resources spent on off‑target detection.