St. Jude Children’s Research Hospital released a new method to detect small off‑target genome changes from base editors, the team said. The approach aims to make precision genome‑editing safety assessment faster and more reliable by identifying subtle edits that standard screens can miss. The method targets an urgent translational need as base‑editing moves toward clinical applications; off‑target small edits are a key safety concern for regulators and developers. The tool should allow researchers and clinicians to better quantify and compare editing platforms during preclinical testing, supporting more informed risk–benefit evaluations ahead of human trials.