St. Jude Children’s Research Hospital released a new method to better identify small off‑target edits produced by base editors, addressing a key safety bottleneck in precision genome editing. The technique aims to improve sensitivity for low‑frequency off‑target sites that are difficult to detect with existing assays. Researchers and clinical developers can apply the method to prioritize safer base‑editing reagents and refine preclinical safety campaigns. Improved off‑target detection tools may accelerate regulatory acceptance and de‑risk therapeutic programs that rely on base‑editing modalities.