Scientists at St. Jude Children’s Research Hospital published a new method to detect small off‑target edits produced by base editors, addressing a major technical and safety challenge in precision genome editing. The approach improves sensitivity for identifying low‑frequency off‑target sites that can pose safety risks in therapeutic settings. The St. Jude team framed the method as a tool to streamline assessment of base‑editor fidelity, reducing time and resource burdens in preclinical development. The publication underlines increasing industry focus on rigorous off‑target surveillance as gene‑editing candidates advance toward clinical translation.