Rice University engineers described a charge-based strategy to improve control over how therapeutic peptides are released from gelatin-based materials. The method targets release behavior by tuning peptide delivery dynamics in relation to the material’s charge properties. Because peptides often suffer from limited stability and suboptimal pharmacokinetics, improved release control from biomaterials is an enabling step for tissue engineering and drug-delivery applications. The study adds a materials-design lever that could help standardize dosing profiles and improve local exposure in regenerative medicine settings.