IRB Barcelona has launched the country’s first end‑to‑end spatial‑omics workflow, uniting core facilities to support academic, clinical and industry users with tissue processing, multiplexed imaging and integrated analysis. The platform aims to shorten translational timelines by providing standardized sample handling, imaging pipelines and data integration for spatial transcriptomics and proteomics. Separately, recent methodological advances show foundation and multi‑modal models are reshaping spatial multi‑omic analysis by linking histopathology images to gene and protein maps. These models—trained on large pathology datasets—enable joint interpretation of spatial modalities and can accelerate biomarker discovery when paired with standardized workflows. The two developments together create an operational stack: national infrastructure to generate high‑quality spatial data and AI models to extract multi‑omic insights. Labs and biopharma should expect improved access to reproducible spatial datasets and an expanding ecosystem of pre‑trained models for pathology‑anchored translational programs.